GYKI-47261 is a AMPA antagonist and a CYP2E1 inducer. GYKI-47261 showed broad spectrum of anticonvulsive and excellent neuroprotective effect. AMPA and NMDA receptors, abundantly expressed on striatal medium spiny neurons, have been implicated in the regulation of corticostriatal synaptic efficacy. References: Bibbiani F, Oh JD, Kielaite A, Collins MA, Smith C, Chase TN. Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD. Exp Neurol. 2005 Dec;196(2):422-9. Epub 2005 Oct 3. PubMed PMID: 16203001.

纯度：≥98%

CAS：220445-20-5