Nebentan, formerly known as YM598, is a n orally bioavailable synthetic substituted phenylethenesulfonamide. As a selective endothelin A receptor antagonist, YM598 inhibits endothelin-mediated mechanisms involved in tumor cell growth and progression, angiogenesis, and metastasis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) References: Ukai M, Yuyama H, Fujimori A, Koakutsu A, Sanagi M, Ohtake A, Sato S, Sudoh K, Sasamata M, Miyata K. In vitro and in vivo effects of endothelin-1 and YM598, a selective endothelin ET A receptor antagonist, on the lower urinary tract. Eur J Pharmacol. 2008 Feb 12;580(3):394-400. Epub 2007 Nov 23. PubMed PMID: 18078923.

纯度：≥98%

CAS：403604-85-3