NCT-502 is an inhibitor of human 3-phosphoglycerate dehydrogenase (PHGDH). NCT-502 reduces the production of glucose-derived serine in cells and suppresses the growth of PHGDH-dependent cancer cells in culture and in orthotopic xenograft tumors. References: Pacold, M.E.,Brimacombe, K.R.,Chan, S.H., et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chemical Biology 12(6), 452-458 (2016).

纯度：≥98%

CAS：1542213-00-2