Corrector C18 is a class I mutation corrector which rescues CFTR mutations in nucleotide-binding domain 1 (NBD1) by modulating proteostasis. References: Chen X, Zhu S, Zhenin M, Xu W, Bose SJ, Wong MP, Leung GPH, Senderowitz H, Chen JH. A defective flexible loop contributes to the processing and gating defects of the predominant cystic fibrosis-causing mutation. FASEB J. 2019 Apr;33(4):5126-5142. doi: 10.1096/fj.201801218RR. Epub 2019 Jan 22. PubMed PMID: 30668920.
纯度:≥98%