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GSK854
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK854图片
CAS NO:1316059-00-3
规格:≥98%
包装与价格:
包装价格(元)
250mg电议
500mg电议
1g电议

产品介绍

GSK854 is a novel and potent TNNI3K (Troponin I-Interacting Kinase) inhibitor with IC50 (TNNI3K) < 10 nM. GSK854 exhibits substantial selectivity against B-Raf (>25-fold) and EGFR (IC50 > 25 μM), excellent broad spectrum kinase selectivity with >100-fold selectivity over 96% of kinases tested (≤50% inhibition @ 1 μM for 282 of 294 kinases, high activity in a TNNI3K cellular assay (IC50 = 8 nM), good pharmacokinetics in rats (Cl = 14 mL/min/kg, Vdss = 1.9 L/kg, t1/2 = 2.3 h, F = 48%).

纯度:≥98%

CAS:1316059-00-3