GSK945237 is a potent inhibitor of bacterial type IIA topoisomerases. GSK945237 shows good Gram-positive and Gram-negative potency and displays good PK and in vivo efficacy properties. References: Miles TJ, Hennessy AJ, Bax B, Brooks G, Brown BS, Brown P, Cailleau N, Chen D, Dabbs S, Davies DT, Esken JM, Giordano I, Hoover JL, Jones GE, Kusalakumari Sukmar SK, Markwell RE, Minthorn EA, Rittenhouse S, Gwynn MN, Pearson ND. Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases. Bioorg Med Chem Lett. 2016 Mar 31. pii: S0960-894X(16)30338-9. doi: 10.1016/j.bmcl.2016.03.106. [Epub ahead of print] PubMed PMID: 27055939.

纯度：≥98%

CAS：944406-54-6