Syntelin is a selectively CENP-E inhibitor. Syntelin inhibited CENP-E motility in a dose-dependent manner with an IC50 of 160 nM. Among an extensive list of mitotic kinesins examined, syntelin was found to be highly selective for CENP-E. Syntelin binds to different sites from those of GSK923295, a recently identified CENP-E ATPase inhibitor, as syntelin inhibits CENP-E mutants resistant to GSK923295 in a manner indistinguishable from that of wild type motor. Syntelin represents a novel class of CENP-E motor inhibitor. References: Ding X, Yan F, Yao P, Yang Z, Wan W, Wang X, Liu J, Gao X, Abrieu A, Zhu T, Zhang J, Dou Z, Yao X. Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin. Cell Res. 2010 Dec;20(12):1386-9. doi: 10.1038/cr.2010.167. Epub 2010 Nov 30. PubMed PMID: 21119683; PubMed Central PMCID: PMC3107503.

纯度：≥98%

CAS：438481-33-5