Dianhydromannitol, Dihyro- and tetrahydrofuran building blocks from 1,4:3,6-dianhydromannitol. 1,2-Anhydro-6-bromo-6-deoxygalactitol (BrEpG) and its D-mannitol analogue (BrEpM) intermediary metabolites in the conversion of dibromodulcitol (DBD) and dibromomannitol (DBM) into dianhydrogalactitol (DAG) and dianhydromannitol (DAM) have been prepared. The three types of analogue of each hexitol have been compared in their toxicities towards mice, tumour inhibitory activities against the Walker carcinosarcoma and haematological effects in rats. The bromoepoxides showed intermediate potency in all tests. The galactitol analogues were always more potent than their mannitol counterparts. The mannitol analogues were selectively myelosuppressive, being twice as toxic towards granulocytes as towards lymphocytes. The lymphotoxic activity of DBM, in particular, relative to its other toxic effects was particularly mild. These differences have been ascribed principally to the more rapid reactivity of DAG compared with DAM towards target nucleophiles, modulated by the influence of the bromine substituent on the transport properties of the dibromo- and bromoepoxy-analogues. References: GREGORY H, WIGGINS LF. Anhydrides of polyhydric alcohols; some alkenyl ethers of 1 : 4-3 : 6-dianhydromannitol and 1 ; 4-3 : 6-dianhydrosorbitol. J Chem Soc. 1947 Oct:1405-7. PubMed PMID: 20272142.

纯度：≥98%

CAS：19895-66-0