GNE-9278 is a potent and selective NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Mutation of a single residue near the Lurcher motif on GluN1 M3 can convert GNE-9278 modulation from positive to negative, and replacing three AMPAR pre-M1 residues with corresponding NMDAR residues can confer GNE-9278 sensitivity to AMPARs. Modulation by GNE-9278 is state-dependent and significantly alters extracellular domain pharmacology. References: Wang TM, Brown BM, Deng L, Sellers BD, Lupardus PJ, Wallweber HJA, Gustafson A, Wong E, Volgraf M, Schwarz JB, Hackos DH, Hanson JE. A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Neuropharmacology. 2017 Jul 15;12204-218. doi: 10.1016/j.neuropharm.2017.04.041. Epub 2017 Apr 27. PubMed PMID: 28457974.

纯度：≥98%

CAS：901230-11-3