GNF6702 is a broad-spectrum antiprotozoal drug invented by researchers working at the Genomics Institute of the Novartis Research Foundation in 2013, with activity against leishmaniasis, Chagas disease and sleeping sickness. These three diseases are caused by related kinetoplastid parasites, which share similar biology. GNF6702 acts as allosteric proteasome inhibitor which was effective against infection with any of the three protozoal diseases in mice, while having little evident toxicity to mammalian cells. References: Smedley CJ, Barrow AS, Spiteri C, Giel MC, Sharma P, Moses JE. Sulfur-Fluoride Exchange (SuFEx)-Mediated Synthesis of Sterically Hindered and Electron-Deficient Secondary and Tertiary Amides via Acyl Fluoride Intermediates. Chemistry. 2017 Jul 26;23(42):9990-9995. doi: 10.1002/chem.201701552. PubMed PMID: 28612408.

纯度：≥98%

CAS：1799329-72-8