Taltirelin (TA-0910; tradename Ceredist) is a thyrotropin-releasing hormone (TRH) analog and a TRH mimic that acts as a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release). Taltirelin alleviates mechanical allodynia through activation of descending monoaminergic neurons in persistent inflammatory pain. Compare to TRH, it has a much longer half-life and duration of effects, and
little development of tolerance following prolonged dosing. It has
nootropic, neuroprotective and analgesic effects