Taminadenant (PBF-509; NIR-178) is a novel, oral and potent adenosine receptor antagonist used as an immunotherapy agent. As a potent and selective A_2A (Adenosine 2A) receptor antagonist, it acts by binding to human A_2A receptor with a Ki value of 12 nM. It inhibits A_2AR expressed on T lymphocytes, thus abrogates the adenosine/ A_2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. It is also reported as a potential pro-dopaminergic drug for Parkinson's disease (PD) management.

纯度：≥98%

CAS：1337962-47-6