GMBS crosslinking reagent, formerly known as N-(Gamma-Maleimidobutyryloxy) Succinimide, is a non-cleavable, water insoluble, heterobifunctional protein crosslinker. GMBS crosslinking reagent is commonly used to crosslink haptens to carrier proteins or enzymes to antibody. GMBS crosslinking reagent's short spacer arm length of 7.3 angstroms and is less immunogenic than the MBS crosslinking reagent analogue. GMBS crosslinking occurs via NHS ester and maleimide reactive groups which react with amino and sulfhydryl moites, respectively. GMBS Crosslinker is useful for making antibody drug conjugates (ADCs). References: Nadeau OW, Anderson DW, Yang Q, Artigues A, Paschall JE, Wyckoff GJ, McClintock JL, Carlson GM. Evidence for the location of the allosteric activation switch in the multisubunit phosphorylase kinase complex from mass spectrometric identification of chemically crosslinked peptides. J Mol Biol. 2007 Feb 2;365(5):1429-45. Epub 2006 Oct 21. PubMed PMID: 17123541; PubMed Central PMCID: PMC1852525.

纯度：≥98%

CAS：80307-12-6