Targapremir-210 (TGP-210) is a novel potent and selective inhibitor of microRNA-210 with anticancer activity. Targapremir-210 inhibits tumorigenesis in a mouse xenograft model of hypoxic triple negative breast cancer. Targapremir-210 selectively recognizes the miR-210 precursor and can differentially recognize RNAs in cells that have the same target motif but have different expression levels, revealing this important feature for selectively drugging RNAs for the first time. Targapremir-210 inhibits pre-miR-210 processing with high binding affinity (Kd~200 nM).

纯度：≥98%

CAS：1049722-30-6