NZ28, formerly known as NSC134754, is potent HSF1 inhibitor, which induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells. Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis. References: Schilling D, Kühnel A, Tetzlaff F, Konrad S, Multhoff G. NZ28-induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells. Cancer Immunol Immunother. 2015 May;64(5):599-608. doi: 10.1007/s00262-015-1665-9. Epub 2015 Feb 18. PubMed PMID: 25854583; PubMed Central PMCID: PMC4412431.

纯度：≥98%

CAS：75041-32-6