CADA, formerly known as Cyclotriazadisulfonamide, is an inhibitor of CD4 biosynthesis at Sec61α, most likely by preventing a reorientation step of the signal sequence in the protein-conducting channel. References: Van Puyenbroeck V, Claeys E, Schols D, Bell TW, Vermeire K. A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA). Mol Cell Proteomics. 2017 Feb;16(2):157-167. doi: 10.1074/mcp.M116.061051. Epub 2016 Dec 20. PubMed PMID: 27998951; PubMed Central PMCID: PMC5294205.
纯度:≥98%
CAS:182316-44-5