TC-2153 is a potent inhibitor of STEP (STriatal-Enriched protein tyrosine Phosphatase) that forms a reversible covalent bond with the catalytic cysteine in STEP. TC-2153 increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B in cell cultures. TC-2153 improves cognitive function in transgenic AD mice. References: Garcia-Forn M, Martínez-Torres S, Barriga GG, Alberch J, Milà M, Azkona G, Pérez-Navarro E. Pharmacogenetic modulation of STEP improves motor and cognitive function in a mouse model of Huntington's disease. Neurobiol Dis. 2018 Aug 31. pii: S0969-9961(18)30517-5. doi: 10.1016/j.nbd.2018.08.024. [Epub ahead of print] PubMed PMID: 30176350.

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CAS：1381769-23-8