FzM1 is the first allosteric ligand of Frizzled4, a member of the Fzd family of Wnt receptors. It acts by specifically signaling downstream of Wnt5a to promote dendrite branching and growth. References: Riccio G, Bottone S, La Regina G, Badolati N, Passacantilli S, Rossi GB, Accardo A, Dentice M, Silvestri R, Novellino E, Stornaiuolo M. A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist. Biochemistry. 2018 Feb 6;57(5):839-851. doi: 10.1021/acs.biochem.7b01087. Epub 2018 Jan 19. PubMed PMID: 29293331.

纯度：≥98%

CAS：1680196-54-6