VU6001376 is a potent and selective mGlu4 PAMs. It has EC50 = 50.1 nM, 50.5% GluMax). It showed selective mGlu4 PAM with an excellent rat DMPK profile (in vivo rat CLp = 3.1 mL/min/kg, t1/2 = 445 min, CYP1A2 IC50 > 30 μM). VU6001376 was also active in reversing haloperidol induced catalepsy in a rodent preclinical model of Parkinson’s disease. References:

纯度：≥98%

CAS：1968546-34-0