FR-181877 is a novel optically pure pyridazinone analogue. It is a nonprostanoid PGI2 agonist. It inhibited ADP-induced aggregation of human platelets with an IC50 of 0.081 microM and has high orally bioavailable bioavailability (56%) with a long half-life (4.3 h) in rats. References: Tsubaki K, Taniguchi K, Tabuchi S, Okitsu O, Hattori K, Seki J, Sakane K, Tanaka H. A novel pyridazinone derivative as a nonprostanoid PGI2 agonist. Bioorg Med Chem Lett. 2000 Dec 18;10(24):2787-90. PubMed PMID: 11133092.

纯度：≥98%

CAS：172936-99-1