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Carbidopa
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Carbidopa图片
CAS NO:28860-95-9
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
Carbidopa (also known as MK485, MK-485; trade name: Lodosyn; abbreviated as CD), a potent and competitive inhibitor of aromatic l-amino acid decarboxylase that does not cross the blood-brain barrier, is routinely administered with levodopa (LD) to patients with Parkinson disease (PD) to reduce the peripheral decarboxylation of LD to dopamine. CD premedication improves 11C-5-HTP PET image quality and facilitates detection of NET lesions. Because of the similarity of metabolic pathways, this method could probably be applied to improve PET imaging using other tracers like 18F-DOPA and 11C-DOPA. Carbidopa (100 microM) decreased growth of (but did not kill) SK-N-SH neuroblastoma and A204 rhabdomyosarcoma cells and did not affect proliferation of DU 145 prostate, MCF7 breast, or NCI-H460 large cell lung carcinoma lines. sublethal doses of carbidopa produced additive cytotoxic effects in carcinoid cells in combination with etoposide and cytotoxic synergy in SCLC cells when coincubated with topotecan.
理化性质和储存条件
Molecular Weight (MW)226.23
FormulaC10H14N2O4
CAS No.28860-95-9
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 4 mg/mL (17.7 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Other info
Chemical Name: (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
InChi Key: TZFNLOMSOLWIDK-JTQLQIEISA-N
InChi Code: InChI=1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1
SMILES Code: O=C(O)[C@@](C)(NN)CC1=CC=C(O)C(O)=C1
Synonyms MK485, MK 485, MK-485, Lodosyn; (S)-(-)-Carbidopa