Description: Pantoprazole Sodium (BY1023; SKF96022; Protonix) is an anti-ulcer drug that acts as a proton pump inhibitor (PPI) and is used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Pantoprazole inhibits the activity of H+/K+-ATPase proton pumb in the parietal cells of gastric mucosa. This inhibition affects the acid secretion and thus, pantoprazole are used as drugs for the treatment of various acid-related disorders. Pantoprazole is activated slowly. The activated sulfonamide of pantoprazole binds to Cys813 and Cys822 of the pumb and inhibits acid secretion selectively.
References: Clin Ther. 2000 Nov;22(11):1268-93.