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Fedratinib(TG101348)dihydrochloride hydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fedratinib(TG101348)dihydrochloride hydrate图片
CAS NO:1374744-69-0
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍

Description:Fedratinib dihydrochloride hydrate (SAR302503 or TG101348) is a novel, potent, selective, orally bioavailable, small-molecule and ATP-competitive inhibitor of janus kinase 2 (JAK2) with the inhibition constant IC50 of 3 nM. The selectivity of TG101348 for JAK2 is 35- and 334-fold stronger than that for JAK3 and JAK1 respectively. TG10348 is capable of inducing apoptosis in HEL cells as well BaF/3 cells harboring JAK2V617 mutation and inhibiting hematopoietic progenitor colony formation and erythroid engraftment in samples from polycythemia vera (PV) patients.

References:Cancer Cell. 2008 Apr;13(4):311-20; Cancer Cell. 2008 Apr;13(4):321-30; Leukemia. 2010 Jul;24(7):1378-80.

Related CAS: 936091-26-8 (free base) 1374744-69-0 (TG101348 dihydrochloride hydrate)

纯度:≥98%

CAS:1374744-69-0