FK-888 is a selective, high affinity tachykinin NK1 receptor antagonist (Ki = 0.69 nM) that exhibits 320-fold selectivity for human over rat NK1 receptors. FK-888 inhibits substance P-induced contraction of isolated guinea pig trachea (IC50 = 32 nM) and inhibits substance P-induced airway constriction in vivo. References: Esposito V, Linard C, Wysocki J, Griffiths NM, Mathe D. A substance P receptor antagonist (FK 888) modifies gut alterations induced by ionizing radiation. Int J Radiat Biol. 1998 Nov;74(5):625-32. PubMed PMID: 9848281.

纯度：≥98%

CAS：138449-07-7