FAUC-365 (FAUC365) is a novel, potent and selective dopamine D3 receptor antagonist with the potential to be used for the treatment of schizophrenia, and Parkinson's disease. It inhibits dopamine D3 receptor with Ki of 0.5 nM. It is selective for dopamine D3 receptors over dopamine D1, D2L, D2S, and D4 receptors (Kis = 8.8, 3.6, 2.6, and 0.34 μM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2 (Kis = 0.36 and 2 μM, respectively). FAUC-365 (1-10 mg/kg) prevents memory impairment in the novel object recognition test in dopamine transporter knockdown (DAT-KD) mice when administered prior to object learning.

纯度：≥98%

CAS：474432-66-1