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Exatecan(DX 8951)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Exatecan(DX 8951)图片
CAS NO:171335-80-1
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍

Exatecan (DX-8951), a semisynthetic and water-soluble analog of camptothecin, is a potent DNA topoisomerase I inhibitor with antineoplastic activity. It inhibits TOP I with an IC50 of 2.2 μM (0.975 μg/mL) and . Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogues.

纯度:≥98%

CAS:171335-80-1