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F-901318(Olorofim)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
F-901318(Olorofim)图片
CAS NO:1928707-56-5
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍

Olorofim (previously F-901318; F901318) is a novel, oral and potent DHODH (dihydroorotate dehydrogenase) inhibitor with a potential for the treatment of invasive aspergillosis. It is the first member of the orotomide class of antifungals. F-901318 exhibit s excellent potency against a broad range of dimorphic and filamentous fungi and is being evaluated in clinical trials for the treatment of invasive mold infections. Olorofim inhibits dihydroorotate dehydrogenase, which is a key enzyme in the biosynthesis of pyrimidines. Olorofim has activity against many molds and thermally dimorphic fungi, including species that are resistant to azoles and amphotericin B, but lacks activity against yeasts and the Mucorales. It is currently being developed for both oral and intravenous administration. Although published clinical outcome data have been limited to case reports to date, the results against invasive and refractory infections are promising.

纯度:≥98%

CAS:1928707-56-5