L-733060 or L-733,060 is an orally bioavailable, non-peptide, selective antagonist for the NK1 receptor, binding with a Ki of 0.08nM. L-733,060 has antidepressant and anxiolytic effects in animal studies, and reduces both the dopamine release and neurotoxicity produced by methamphetamine and cocaine. It shows antiinflammatory and anti-hepatotoxic effects in animals, and counteracts the development of hyperalgesia following nerve injury.[15][16] It also has anticancer effects in a variety of in vitro models. References: Pansare SV, Paul EK. Synthesis of (+)-L-733,060, (+)-CP-99,994 and (2S,3R)-3-hydroxypipecolic acid: application of an organocatalytic direct vinylogous aldol reaction. Org Biomol Chem. 2012 Mar 14;10(10):2119-25. doi: 10.1039/c2ob06644k. Epub 2012 Jan 31. PubMed PMID: 22294285.

纯度：≥98%

CAS：148687-76-7