CAS NO: | 62774-96-3 |
包装: | 50mg, 100mg, 250mg |
规格: | ≥98% |
Tilisolol, formerly known as N-696, is a nonselective beta-adrenergic blocker. Tilisolol hydrochloride dilates coronary arteries through an ATP-sensitive K(+)-channel opening mechanism in dogs. In contrast to propranolol, N-696 lowered blood pressure and heart rate without peripheral vasoconstriction and did not augment forearm vasoconstrictive responses to norepinephrine. References: Kawakami S, Ohshima N, Hirayama R, Al MH, Kitahara T, Sakaeda T, Mukai T, Nishida K, Nakamura J, Nakashima M, Sasaki H. Biodistribution and pharmacokinetics of O-palmitoyl tilisolol, a lipophilic prodrug of tilisolol, after intravenous administration in rats. Biol Pharm Bull. 2002 Aug;25(8):1072-6. PubMed PMID: 12186412.
纯度:≥98%
CAS:62774-96-3