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Tozadenant
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tozadenant图片
CAS NO:870070-55-6
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍

Tozadenant (formerly RO-4494351; SYN-115) is an orally bioavailable, selective adenosine A2A receptor antagonist with potential usefulness in the treatment of Parkinson disease (PD). It inhibits A2A receptor with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A. It improves motor function in animal models of Parkinson's disease. Adenosine A(2a) receptor antagonists reduce symptom severity in Parkinson disease (PD) and animal models. Rodent studies support the hypothesis that A(2a) antagonists produce this benefit by reducing the inhibitory output of the basal ganglia indirect pathway.

纯度:≥98%

CAS:870070-55-6