您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > CGP-28014
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
CGP-28014
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:111757-17-6
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

CGP-28014 is a catechol-O-methyltransferase inhibitor potentially for the treatment of Parkinson's disease.Although CGP-28014 increases the renal excretion of both dopamine and dihydroxyphenylacetic acid (DOPAC) it does not affect renal sodium handling indicating a different mechanism of action. CGP-28014 significantly reduced the levels of homovanillic acid (HVA), but did not modify DA and 3,4-dihydroxyphenylacetic acid (DOPAC). References: Kambur O, Talka R, Ansah OB, Kontinen VK, Pertovaara A, Kalso E, Mannisto PT. Inhibitors of catechol-O-methyltransferase sensitize mice to pain. Br J Pharmacol. 2010 Dec;161(7):1553-65. doi: 10.1111/j.1476-5381.2010.00999.x. PubMed PMID: 20726980; PubMed Central PMCID: PMC3010567.

纯度:≥98%

CAS:111757-17-6