E1R is a novel positive allosteric modulator of sigma-1 receptors. E1R is a novel 4,5-disubstituted analogue of piracetam that enhances cognition and displays efficacy against scopolamine-induced cholinergic dysfunction in mice. References: Saulite L, Vavers E, Zvejniece L, Dambrova M, Riekstina U. The Differentiation of Skin Mesenchymal Stem Cells Towards a Schwann Cell Phenotype: Impact of Sigma-1 Receptor Activation. Mol Neurobiol. 2017 Apr 28. doi: 10.1007/s12035-017-0511-9. [Epub ahead of print] PubMed PMID: 28455697.
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CAS:1301211-78-8