DuP-697 (S-6907 and BFMT) is an irreversible, selective and orally bioactive cyclooxygenase 2 (COX-2) inhibitor with the potential for the treatment of rheumatoid arthritis (RA) and osteoarthritis and with IC50 of 10 nM and 800 nM for human COX-2 and COX-1, respectively. DuP-697 alone exerted antiproliferative, antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. DuP-697 significantly suppressed K562 cells and primary CML cells growth and induced apoptosis in a concentration-dependent manner and the growth-inhibiting effect was independent on Philadelphia chromosome. DuP-697, at concentrations ranges which do not inhibit PGHS-1 activity, significantly attenuated the inhibition of PGHS-1 that was caused by aspirin and indomethacin.

纯度：≥98%

CAS：88149-94-4