DSP 4 is a selective neurotoxin selective for noradrenergic neurons in the locus coeruleus noradrenergic system and capable of crossing the blood–brain barrier and cyclizes to a reactive aziridinium analogue that is accumulated into the noradrenergic nerve terminals via the noradrenaline transporter. References: Ross SB, Stenfors C. DSP4, a selective neurotoxin for the locus coeruleus noradrenergic system. A review of its mode of action. Neurotox Res. 2015 Jan;27(1):15-30. doi: 10.1007/s12640-014-9482-z. Epub 2014 Jun 26. Review. PubMed PMID: 24964753.
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CAS:62078-98-2