您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Rineterkib(LTT-462 ERK-IN-1)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Rineterkib(LTT-462 ERK-IN-1)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rineterkib(LTT-462 ERK-IN-1)图片
CAS NO:1715025-32-3
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议

产品介绍
理化性质和储存条件


Molecular Weight: 578.42
Formula: C26H27BrF3N5O2
CAS No.: 1715025-32-3
SMILES: O=C(N[C@@H](C1=CC(F)=CC(Br)=C1)CNC)C2=CC=C(C3=NC([C@@H]4C[C@H](F)[C@@H](O)CC4)=CN=C3N)C=C2F
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Technical InformationERK-IN 1; ERK IN-1; ERK-IN-1
实验参考方法
Target

RAF; ERK1; ERK2

In VivoERK-IN-1 (compound B) (50, 75 mg/kg, p.o., qd/q2d, 27 days) treatment significantly reduces the tumor volume in the Calu-6 human NSCLC subcutaneous tumor xenograft model in mice[1]. Animal Model: Calu-6 NSCLC xenograft tumor models in mice[1]. Dosage: 50, 75 mg/kg. Administration: Orally either daily (qd) or every other day (q2d) for 27 days. Result: Significantly reduced the tumor volume.
References

[1]. WO2018051306A1