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DT-061
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DT-061图片
CAS NO:1809427-19-7
规格:≥98%
包装与价格：
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍
理化性质和储存条件


Name: DT-061
CAS#: 1809427-19-7
Chemical Formula: C25H23F3N2O5S
Exact Mass: 520.128
Molecular Weight: 520.5232
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Technical InformationSynonym: DT 061; DT61; SMAP; DT-061; DT061; DT-61; DT 61
Chemical Name: N-((1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl)-4-(trifluoromethoxy)benzenesulfonamide
InChi Key: WGKGADVPRVLHHZ-ZHRMCQFGSA-N
InChi Code: InChI=1S/C25H23F3N2O5S/c26-25(27,28)35-16-12-14-17(15-13-16)36(32,33)29-18-6-5-9-21(24(18)31)30-19-7-1-3-10-22(19)34-23-11-4-2-8-20(23)30/h1-4,7-8,10-15,18,21,24,29,31H,5-6,9H2/t18-,21+,24+/m1/s1
SMILES Code: O=S(C1=CC=C(OC(F)(F)F)C=C1)(N[C@H]2[C@H](O)[C@@H](N3C4=C(C=CC=C4)OC5=CC=CC=C35)CCC2)=O
实验参考方法
Target

PP2A[1].

In VivoDT-061 (5 mg/kg, oral gavage, 4 weeks) shows single-agent activity in inhibiting H358 or H441 xenograft growth. Additionally, the combination of DT-061 and AZD6244 is more significantly efficient[1]. Animal Model: 6- to 8-week-old male BALB/c nu/nu mice injected with H441 cells (5 × 106)[1]. Dosage: 5 mg/kg. Administration: Oral gavage for 4 weeks. Result: Showed activity in inhibiting tumor growth.
References

[1]. Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093.