DMP-777 formerly known as L 694458, is a potent and orally bioavailable Leukocyte elastase (HLE) inhibitor. orally bioavailable dosing with DMP 777 caused a rapid increase in serum gastrin levels and severe hypochlorhydria. DMP 777 inhibited aminopyrine accumulation into rabbit parietal cells stimulated with either histamine or forskolin. DMP 777 reversed a stimulated proton gradient in isolated parietal cell tubulovesicles. DMP 777 acts as a protonophore with specificity for parietal cell acid-secretory membranes. DMP 777 in high doses leads to the specific loss of parietal cells. References: Yamagata Y, Aikou S, Fukushima T, Kataoka H, Seto Y, Esumi H, Kaminishi M, Goldenring JR, Nomura S. Loss of HGF activator inhibits foveolar hyperplasia induced by oxyntic atrophy without altering gastrin levels. Am J Physiol Gastrointest Liver Physiol. 2012 Dec 1;303(11):G1254-61. doi: 10.1152/ajpgi.00107.2012. Epub 2012 Oct 11. PubMed PMID: 23064758; PubMed Central PMCID: PMC4888532.

纯度：≥98%

CAS：157341-41-8