Description: Disufenton (NXY-059; Cerovive, OKN007) is a disulfonyl derivative that has shown a significant differences in arterial Po2 and pH between the experimental groups before ischemia in BBB permeability study with Po2 value of 112.9±9.7mm Hg and pH value of 7.443±0.01. In addition, in rats, NXY-059 has been reported to significantly improve neurologic deficits at 24 hours when given at 6 hours of reperfusion. Besides, treatment with NXY-059 has been revealed to significantly ameliorate the brain damage. Thereby, the mean volumes of infarct and total damage are reduced to 9.2±14.8%（P<0.05） and 10.9±15.8%(P<0.01), respectively.

References: J Cereb Blood Flow Metab. 1999 Jul;19(7):778-87; Stroke. 2001 Jan;32(1):190-8; Brain Res. 2009 Oct 19;1294:144-52.

Related CAS #: 168021-79-2 (sodium) 168021-77-0 (free acid)

纯度：≥98%

CAS：168021-77-0