Description: Hydroxyzine pamoate is a potent histamine H1-receptor antagonist which inhibits the binding of [3H]pyrilamine/[3H]desloratadine to human histamine H1 receptor with IC50 of 10 nM/19 nM. Hydroxyzine inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min. Hydroxyzine (0.1 mM) treatment inhibits the progression and severity of EAE by 50% and the extent of mast cell degranulation by 70% in Lewis rats with allergic encephalomyelitis (EAE). Unlike its major metabolite cetirizine, Hydroxyzine does cause drowsiness.

References: Int J Immunopharmacol. 1998 Oct;20(10):553-63; Anticancer Drugs. 2001 Mar;12(3):267-73.

Related CAS #:68-88-2 (free base); 1244-76-4 (HCl); 10246-75-0 (pamoate); 5978-92-7 (pamoate ester); 1189480-47-4 (Hydroxyzine D8);

纯度：≥98%

CAS：10246-75-0