VU0240551 is an inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells). VU0240551 exhibits selectivity over the Na-K-2Cl cotransporter, NKCCl. It also inhibits hERG and L-type Ca2+ channels. References: Gu W, Zhang W, Lei Y, Cui Y, Chu S, Gu X, Ma Z. Activation of spinal alpha-7 nicotinic acetylcholine receptor shortens the duration of remifentanil-induced postoperative hyperalgesia by upregulating KCC2 in the spinal dorsal horn in rats. Mol Pain. 2017 Jan-Dec;13:1744806917704769. doi: 10.1177/1744806917704769. PubMed PMID: 28425312.

纯度：≥98%

CAS：893990-34-6