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Paliperidone palmitate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Paliperidone palmitate图片
CAS NO:199739-10-1
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件


Name: Paliperidone Palmitate
CAS#: 199739-10-1
Chemical Formula: C39H57FN4O4
Exact Mass: 664.4364
Molecular Weight: 664.9074
Elemental Analysis: C, 70.45; H, 8.64; F, 2.86; N, 8.43; O, 9.62
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Technical InformationSynonym: RO 92670; RO-92670; RO92670.
IUPAC/Chemical Name: Hexadecanoic acid, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido(1,2-a)pyrimidin-9-yl ester
InChi Key: VOMKSBFLAZZBOW-UHFFFAOYSA-N
InChi Code: InChI=1S/C39H57FN4O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-18-36(45)47-34-17-16-24-44-38(34)41-29(2)32(39(44)46)23-27-43-25-21-30(22-26-43)37-33-20-19-31(40)28-35(33)48-42-37/h19-20,28,30,34H,3-18,21-27H2,1-2H3
SMILES Code: CCCCCCCCCCCCCCCC(OC1CCCN(C1=NC(C)=C2CCN3CCC(C4=NOC5=C4C=CC(F)=C5)CC3)C2=O)=O
实验参考方法

In Vitro

In vitro activity: Paliperidone significantly increases the intracellular accumulation of Rh123 and DOX in a concentration-dependent manner. Paliperidone works finely at low concentrations (10 and 50 μM) against Aβ(25-35) and MPP(+) and solely protects SH-SY5Y from hydrogen peroxide. Paliperidone (100 μM) completely diminishes cell reduction induced by different stressors, regardless of their dosages. Paliperidone is demonstrated with higher oxidative stress-scavenging properties than other APDs in several aspects, such as generated bulk glutathione, low HNE, and protein carbonyl productions. Paliperidone enhances dopamine toxicity at the highest dose and is the only AP that significantly increases cell viability (8.1%) compared with cells treated with dopamine alone.

In VivoPaliperidone normalizes prefrontal cortical basal extracellular glutamate in rats. Paliperidone also prevents the acute MK-801-induced increase in extracellular glutamate in rats. Paliperidone coadministered with Escitalopram restores the suppression of the NE neuronal firing rate (n = 5 rats) and the percentage of neurons exhibiting burst firing. Paliperidone results in a dose-dependent decrease in bite and attack behaviors with an effective dose. Paliperidone results in the maximal reduction in aggressive behavior.
Animal modelRats
Formulation & DosageN/A
References

Neuropsychopharmacology. 2007 Apr;32(4):757-64; Neurosci Lett. 2011 Aug 18;500(3):167-71.