DFL23448 is a TRPM8-selective ion channel antagonist, modifying bladder function and reduces bladder overactivity in awake rats. References: De Caro C, Russo R, Avagliano C, Cristiano C, Calignano A, Aramini A, Bianchini G, Allegretti M, Brandolini L. Antinociceptive effect of two novel transient receptor potential melastatin 8 antagonists in acute and chronic pain models in rat. Br J Pharmacol. 2018 May;175(10):1691-1706. doi: 10.1111/bph.14177. Epub 2018 Apr 14. PubMed PMID: 29485712; PubMed Central PMCID: PMC5913409.
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CAS:1445753-16-1