Amiodarone is an effective antiarrhythmic drug handicapped by serious side effects. The mechanism of its antiarrhythmic activity is not known but is presumed to involve inhibition of current flowing through ion channels. Des-oxo-amiodarone, a close structural analogue of amiodarone, blocks cardiac ion channels. References: Rafeiro E, Leeder RG, Brien JF, Kabalka GW, Chatla N, Massey TE. Comparison of the in vivo pulmonary toxicity of amiodarone and des-oxo-amiodarone in the hamster. Toxicol Appl Pharmacol. 1994 Aug;127(2):275-81. PubMed PMID: 8048071.

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CAS：116523-57-0