生物活性
Dabigatran etexilate mesylate是达比加群的口服活性前药。达比加群是一种可逆的选择性直接凝血酶抑制剂（DTI），Ki值为4.5 nM。
化学数据
| 目录号 | A15057 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 723.84 |
| Formula | C35H45N7O8S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 872728-81-9 |
| Synonyms | Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate |
| SMILES | CCCCCCOC(=O)N=C(C1=CC=C(C=C1)NCC2=NC3=C(N2C)C=CC(=C3)C(=O)N(CCC(=O)OCC)C4=CC=CC=N4)N.CS(=O)(=O)O |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 13.82 mL | 69.08 mL | 138.15 mL |
| 0.5 mM | 2.76 mL | 13.82 mL | 27.63 mL |
| 1 mM | 1.38 mL | 6.91 mL | 13.82 mL |
| 5 mM | 0.28 mL | 1.38 mL | 2.76 mL |
*The above data is based on the productmolecular weight 723.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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