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Carboxyamidotriazole Orotate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:187739-60-2
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

Carboxyamidotriazole orotate (CTO) is t he orotate salt form of carboxyamidotriazole (CAI), an orally bioavailable small molecule with potential antiangiogenic and antiproliferative activities. Carboxyamidotriazole binds to and inhibits non-voltage-operated calcium channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores, resulting in the disruption of calcium channel-mediated signal transduction. CAI inhibits PI3 activity and vascular endothelial growth factor (VEGF) signaling. This may inhibit endothelial proliferation, tumor cell growth, invasion and metastasis. References: Ju R, Wu D, Guo L, Li J, Ye C, Zhang D. Inhibition of pro-inflammatory cytokines in tumour associated macrophages is a potential anti-cancer mechanism of carboxyamidotriazole. Eur J Cancer. 2011 Jul 16. [Epub ahead of print] PubMed PMID: 21767946.

纯度:≥98%

CAS:187739-60-2