CC-1088 is an analogue of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs inhibit phosphodiesterase-4 (PDE 4), an enzyme involved in tumor necrosis factor alpha (TNF alpha) production. CC-1088 inhibits production of the cytokines vascular endothelial growth factor (VEGF) (a pro-angiogenic factor) and interleukin-6 (IL-6). References: Dredge K. CC-1088 Celgene. Curr Opin Investig Drugs. 2005 May;6(5):513-7. Review. PubMed PMID: 15912966.

纯度：≥98%

CAS：467421-06-3