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Dads-E
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:108736-70-5
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

Dads-E can be used in use of diaminodithiol for labeling small molecules with technetium-99m.The estrone analogue was prepared by alkylation of DADS while the fatty acid analogue -N,N'-bisethylenediamine hydrochloride, DADT-FA) was synthesized by alkylation of DADS followed by reduction. DADS-E was labeled in ethanol at elevated temperatures while DADT-FA was labeled at room temperature, both by stannous reduction. Paper chromatography showed both to be labeled and reverse-phase HPLC showed multiple peaks for both. Serum stability studies were performed by incubation at 37 degrees C with aliquots removed at 1 min and 1 day for analysis by size-exclusion HPLC. Initially, little pertechnetate or binding to serum proteins was observed whereas after 1 day the majority of activity in both cases was protein bound with 20 and 38% pertechnetate appearing for DADT-FA and DADS-E respectively. References: Liang FH, Virzi F, Hnatowich DJ. The use of diaminodithiol for labeling small molecules with technetium-99m. Int J Rad Appl Instrum B. 1987;14(1):63-7. PubMed PMID: 3583757.

纯度:≥98%

CAS:108736-70-5