Dactylarin is cytotoxic antibiotic. Dactylarin extracted from Dactylaria lutea (Deuteromycetes). Cytotoxic effect of dactylarin on Ehrlich ascites carcinoma cells is caused by the inhibition of some SH-dependent glycolytic enzymes, especially of hexokinase (EC 2.7.1.1), glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) and 6-phosphofructokinase (EC 2.7.1.11). Dactylarin interacts with thiols, which explains its inhibitory effectiveness on the above glycolytic enzymes. References: Sturdík E, Drobnica L. Interaction of cytotoxic antibiotic dactylarin with glycolytic thiol enzymes in Ehrlich ascites carcinoma cells. J Antibiot (Tokyo). 1981 Jun;34(6):708-12. PubMed PMID: 6456251.

纯度：≥98%

CAS：22350-90-9