CE-245677 is a selective, orally bioavailable Tie2 kinase inhibitor identified by Pfizer previously in development for the treatment of certain cancers. CE-245,677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, resp., exhibits >100x selectivity against a number of other angiogenic receptor tyrosine kinases (e.g. KDR, PDGFR, FGFR) and gene family panels, and displays good orally bioavailable absorption in in vivo rat PK studies (F=80%). References:

纯度：≥98%

CAS：717899-97-3