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Ceftobiprole(Ro 63-9141 BAL 9141)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ceftobiprole(Ro 63-9141 BAL 9141)图片
CAS NO:209467-52-7
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍

Description: Ceftobiprole (Ro-63-9141; BAL 9141) is a fifth-generation and broad-spectrum cephalosporin prodrug for the treatment of hospital-acquired pneumonia and community-acquired pneumonia. Like other cephalosporins, ceftobiprole exerts its antibacterial activity by binding to important penicillin-binding proteins and inhibiting their transpeptidase activity which is essential for the synthesis of bacterial cell walls. Ceftobiprole has high affinity for penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus strains and retains its activity against strains that express divergent mecA gene homologues. Ceftobiprole also binds to penicillin-binding protein 2b in Streptococcus pneumoniae, to penicillin-binding protein 2x in Streptococcus pneumoniae, and to penicillin-binding protein 5 in Enterococcus faecalis.

References:

[1].Kisgen J, et al. Ceftobiprole, a Broad-Spectrum Cephalosporin With Activity against Methicillin-ResistantStaphylococcus aureus(MRSA). P T. 2008 Nov;33(11):631-41.

[2].Hodille E, et al. In vitro activity of ceftobiprole on 440Staphylococcus aureusstrains isolated from bronchopulmonary infections. Med Mal Infect. 2017 Mar;47(2):152-157.

[3]. Ceftobiprole for the treatment of pneumonia: a European perspective. Drug Des Devel Ther. 2015 Aug 18;9:4565-72. doi: 10.2147/DDDT.S56616. eCollection 2015.

纯度:≥98%

CAS:209467-52-7